What is papaya soap? Papaya soap is a natural, gentle soap that’s safe to use on different parts of the body, including the face. A normal bar of soap also cleans and removes dirt. But it may be too harsh for the skin, stripping it of natural oils. Some soaps contain synthetic detergents and other ingredients that will not only wash away dirt but also your skin’s natural moisture. This can exacerbate skin conditions like acne, psoriasis, and rosacea, increasing dryness and itchiness. Papaya soap, on the other hand, is made from natural ingredients. It contains the enzyme papain, which breaks down protein. This enzyme promotes healthy digestion, but it can also act as an anti-inflammatory.